Description
HDAC-8, human recombinant is available at Gentaur for Next week delivery.
Critical regulator of transcription, cell cycle progression, and developmental events
Biomolecule/Target:
Alternates names: HDAC-8,HDACL1, Histone deacetylase 8
Synonyms: HDAC-8,HDACL1, Histone deacetylase 8
Background Information: Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).
Reconstitution Instructions: N/A
NCBI Gene Symbol: HDAC8
Gene ID: 55869
NCBI Accession: Q9BY41
Additional Information
Size: |
20 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
Sf9 insect cells |
Purity by SDS-PAGE: |
≥90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
Activity of rh-HDAC8 was tested using Arg-His-Lys(Ac)-Lys(Ac)-AFC, a fluorogenic, acetylated peptide based on residues 379-382 of p53 as a substrate. |
Biological activity: |
N/A |
Results: |
N/A |
Molecular Weight: |
44 kDa |
Storage Temperature: |
-80°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |