ANGPTL-3, Human Recombinant

ANGPTL-3, Human Recombinant is available at Gentaur for Next week delivery.

Inhibits lipoprotein lipase (LPL) and endothelial lipase (EL)

Biomolecule/Target: ANGPTL-3

Alternates names: Angiopoietin-like protein 3, ANG-5, ANGPT5, Angiopoietin-5, Angiopoietin-related protein 3, ANGPTL3

Synonyms: Angiopoietin-like protein 3, ANG-5, ANGPT5, Angiopoietin-5, Angiopoietin-related protein 3, ANGPTL3

Background Information: ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It is primarily expressed in the liver and can exert activities related to both angiogenesis and lipid metabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), which has the effect of increasing plasma levels of triglycerides and HDL associated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein can bind alpha-5/beta-3 integrin’s leading to endothelial cell adhesion and migration. Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE analysis at an apparent molecular weight of 62 kDa, and contains 452 amino acid residues including a C-terminal His tag.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: ANGPTL3

Gene ID:

NCBI Accession: Q9Y5C1