Description
HDAC-3, human recombinant is available at Gentaur for Next week delivery.
A potential tumor suppressor gene
Biomolecule/Target:
Alternates names: Histone deacetylase 3, HD3, RPD3-2, SMAP45
Synonyms: HDAC-3, HDAC3, HDAC 3, Histone deacetylase 3
Background Information: Human Histone Deacetylase 3 (HDAC3) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Like other class I and II HDAC members, the activity of HDAC3 is sensitive to HDAC inhibitor Trichostatin A (TSA).
Reconstitution Instructions: N/A
NCBI Gene Symbol: HDAC3
Gene ID: 8841
NCBI Accession: O15379
Additional Information
Size: |
250 units |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
Sf9 insect cells |
Purity by SDS-PAGE: |
≥50% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
Activity of rh-HDAC3 was tested using Arg-His-Lys-Lys(Ac)-AFC, a fluorogenic, acetylated peptide based on residues 379-382 of p53 as a substrate. ≥ 0.5 U/µl |
Biological activity: |
N/A |
Results: |
N/A |
Molecular Weight: |
51.1kDa |
Storage Temperature: |
-80°C |
Shelf Life: |
12 months |
Concentration: |
0.5U/µl |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |