Glyoxalase II (Glx II), Human Recombinant

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SKU:
P1072-50
$719.07
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Description

Glyoxalase II (Glx II), Human Recombinant is available at Gentaur for Next week delivery.

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

Biomolecule/Target: HAGH

Alternates names: Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2

Synonyms: Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2

Background Information: The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis.

Reconstitution Instructions: N/A

NCBI Gene Symbol: HAGH

Gene ID: 3029

NCBI Accession: Q16775

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
≥ 10 U/mg , in which one unit is the amount of enzyme that will hydrolyze 1.0 µmole of SLG per minute at pH 7.4 at 25 ̊C.
Results:
≥ 10 U/mg
Molecular Weight:
32.4 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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