Glyoxalase II (Glx II), Human Recombinant

Glyoxalase II (Glx II), Human Recombinant is available at Gentaur for Next week delivery.

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

Biomolecule/Target: HAGH

Alternates names: Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2

Synonyms: Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2

Background Information: The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis.

Reconstitution Instructions: N/A

NCBI Gene Symbol: HAGH

Gene ID: 3029

NCBI Accession: Q16775