BioVision Proteins
Glyoxalase II (Glx II), Human Recombinant
- SKU:
- P1072-50
Description
Glyoxalase II (Glx II), Human Recombinant is available at Gentaur for Next week delivery.
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Biomolecule/Target: HAGH
Alternates names: Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2
Synonyms: Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2
Background Information: The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis.
Reconstitution Instructions: N/A
NCBI Gene Symbol: HAGH
Gene ID: 3029
NCBI Accession: Q16775
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli |
Purity by SDS-PAGE: |
≥90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
N/A |
Biological activity: |
≥ 10 U/mg , in which one unit is the amount of enzyme that will hydrolyze 1.0 µmole of SLG per minute at pH 7.4 at 25 ̊C. |
Results: |
≥ 10 U/mg |
Molecular Weight: |
32.4 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |