Description
Angiostatin K1-3, human recombinant is available at Gentaur for Next week delivery.
A specific inhibitor of endothelial cell growth and angiogenesis
Biomolecule/Target:
Alternates names: Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen
Synonyms: Angiostatin K1-3, Angiostatin Kringles 1-3
Background Information: Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀ =70 nM) relative to kringles 1-4 (ED₅₀ = 135 nM). Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.
Reconstitution Instructions: Reconstitute in sterile distilled H₂O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
NCBI Gene Symbol:
NCBI Accession: P00747
Additional Information
Size: |
20 μg |
Adwords: |
yes |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
≥95% |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
N/A |
Biological activity: |
The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 0.55×10⁵ Units/mg. |
Results: |
0.55×10⁵ Units/mg. |
Molecular Weight: |
30.0 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized protein |
Handling: |
Centrifuge the vial prior to opening. |
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