Angiostatin K1-3, human recombinant

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SKU:
4920-20
€185
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Description

Angiostatin K1-3, human recombinant is available at Gentaur for Next week delivery.

A specific inhibitor of endothelial cell growth and angiogenesis

Biomolecule/Target:

Alternates names: Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen

Synonyms: Angiostatin K1-3, Angiostatin Kringles 1-3

Background Information: Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀ =70 nM) relative to kringles 1-4 (ED₅₀ = 135 nM). Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.

Reconstitution Instructions: Reconstitute in sterile distilled H₂O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.

NCBI Gene Symbol:

Gene ID:

NCBI Accession: P00747

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Additional Information

Size:
20 μg
Adwords:
yes
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
≥95%
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 0.55×10⁵ Units/mg.
Results:
0.55×10⁵ Units/mg.
Molecular Weight:
30.0 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized protein
Handling:
Centrifuge the vial prior to opening.
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