Active sFRP-4, Human Recombinant

Active sFRP-4, Human Recombinant is available at Gentaur for Next week delivery.

A soluble modulator of Wnt signaling

Biomolecule/Target:

Alternates names:

Synonyms: Secreted frizzled-related protein 4; DDC-4 SFRP4, FRP-4, FRPHE, PYL Frizzled protein, human endometrium; FRP-AP; frpHE; FRPHEMGC26498; FrzB2

Background Information: Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.

Reconstitution Instructions: Reconstitute to desired concentration using sterile water.

NCBI Gene Symbol:

Gene ID: 6424

NCBI Accession: Q6FHJ7