Description
Active MANF, Human Recombinant is available at Gentaur for Next week delivery.
A secreted neurotrophic factor that is mutated in a variety of tumors
Biomolecule/Target:
Alternates names:
Synonyms: arginine-rich, mutated in early stage tumors; Protein ARMET Mesencephalic Astrocyte-derived Neurotrophic Factor, ARMET, Arginine-rich protein (ARP)
Background Information: MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.
Reconstitution Instructions: Reconstitute to desired concentration using sterile water
NCBI Gene Symbol:
Gene ID: 7873
NCBI Accession: P55145
Additional Information
Size: |
25 µg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
True |
Source: |
E.coli |
Purity by SDS-PAGE: |
≥ 98% by SDS-PAGE gel and HPLC analyses |
Biological activity: |
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml. |
Molecular Weight: |
18.1 kDa |
Storage Temperature: |
-20ºC |
Shelf Life: |
12 months |
Appearance: |
Lyophilized powder |
Handling: |
Centrifuge the vial prior to opening. |