Active MANF, Human Recombinant

Active MANF, Human Recombinant is available at Gentaur for Next week delivery.

A secreted neurotrophic factor that is mutated in a variety of tumors

Biomolecule/Target:

Alternates names:

Synonyms: arginine-rich, mutated in early stage tumors; Protein ARMET Mesencephalic Astrocyte-derived Neurotrophic Factor, ARMET, Arginine-rich protein (ARP)

Background Information: MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.

Reconstitution Instructions: Reconstitute to desired concentration using sterile water

NCBI Gene Symbol:

Gene ID: 7873

NCBI Accession: P55145