Active MANF, Human Recombinant

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SKU:
P1706-25
$719.07
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Description

Active MANF, Human Recombinant is available at Gentaur for Next week delivery.

A secreted neurotrophic factor that is mutated in a variety of tumors

Biomolecule/Target:

Alternates names:

Synonyms: arginine-rich, mutated in early stage tumors; Protein ARMET Mesencephalic Astrocyte-derived Neurotrophic Factor, ARMET, Arginine-rich protein (ARP)

Background Information: MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.

Reconstitution Instructions: Reconstitute to desired concentration using sterile water

NCBI Gene Symbol:

Gene ID: 7873

NCBI Accession: P55145

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Additional Information

Size:
25 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
True
Source:
E.coli
Purity by SDS-PAGE:
≥ 98% by SDS-PAGE gel and HPLC analyses
Biological activity:
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.
Molecular Weight:
18.1 kDa
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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