Description
Active SIRT7, human recombinant is available at Gentaur for Next week delivery.
Intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
Biomolecule/Target: SIRT7
Alternates names: NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7
Synonyms: NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7
Background Information: The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
Reconstitution Instructions: N/A
NCBI Gene Symbol: SIRT7
Gene ID: 51547
NCBI Accession: Q9NRC8
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli |
Purity by SDS-PAGE: |
≥85% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
BioVision’s Active His-tagged SIRT7 has been tested for its activity using Sirtuin Activity Assay Kit (K324-100). It has a specific activity of >1 µU/mg. |
Biological activity: |
>1 µU/mg |
Results: |
>1 µU/mg |
Molecular Weight: |
50.1 kDa (2-400 aa + N-terminal polyhistidine tag). |
Storage Temperature: |
-80°C |
Shelf Life: |
6 months |
Concentration: |
2 mg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |