Active Cathepsin S, human recombinant

Active Cathepsin S, human recombinant is available at Gentaur for Next week delivery.

A lysosomal cysteine protease participating in the degradation of antigenic proteins to peptides

Biomolecule/Target: Cathepsin S

Alternates names: CTSS

Synonyms: CTSS

Background Information: Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.

Reconstitution Instructions: Reconstitute in 50 mM sodium acetate, 100 mM NaCl (pH 5.5) to 0.1-1 mg/ml

NCBI Gene Symbol: CTSS

Gene ID: 1520

NCBI Accession: P25774