Active Cathepsin D, Human Recombinant

Active Cathepsin D, Human Recombinant is available at Gentaur for Next week delivery.

An active Lysosomal aspartyl protease

Biomolecule/Target: Cathepsin D

Alternates names: Procathepsin D, CTSD

Synonyms: Procathepsin D, CTSD

Background Information: Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D. BioVision’s Active Human Cathepsin D is a proteolytically active, non-glycosylated enzyme expressed, purified and activated by proprietary methods.

Reconstitution Instructions: Reconstitute to 1 mg/ml in water

NCBI Gene Symbol: CTSD

Gene ID: 1509

NCBI Accession: P07340