Active Caspase-1, rat recombinant

Active Caspase-1, rat recombinant is available at Gentaur for Next week delivery.

A cysteine protease involved in apoptosis

Biomolecule/Target: Caspase-1

Alternates names: Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1BC, p45.

Synonyms: Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1BC, p45.

Background Information: Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant rat caspase-1 was expressed in E. coli as a single polypeptide of 284 amino acids with molecular weight of 34.6. The caspase-1 is purified and activated by proprietary techniques.

Reconstitution Instructions: Reconstitute to 1 unit per μl in PBS containing 15% glycerol.

NCBI Gene Symbol: Casp1

Gene ID: N/A

NCBI Accession: P43527