CD54 (ICAM1) FITC Monoclonal Antibody (Clone 15.2)

CD54 (ICAM1) FITC Monoclonal Antibody (Clone 15.2)is available at Gentaur for Next week Delivery.

Description: Inter-Cellular Adhesion Molecule 1 (ICAM-1), also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds. The 15.2 antibody reacts with the 85-110 kDa ICAM-1.

Immunogen Sequence:Human CD54/ICAM1

Target Alternative Name:CD54/ICAM1

Species Reactivities:Human

Tag Line:Mouse monoclonal FITC conjugated antibody to detect CD54/ICAM in human samples.

Formulation:Phosphate-buffered aqueous solution pH 7.2, ≤0.09% Sodium azide, may contain carrier protein/stabilizer.

Purification: Affinity chromatography.

Application:Flow cytometry

Positive Control:FACS: Human peripheral blood lymphocytes

Application And Usages:Flow (Cell Surface): 5 µl/1x10^6 cells, Volume per test: 5 µl (0.5 µg).

Handling:The antibody solution should be gently mixed before use.