CD45RO FITC Monoclonal Antibody (Clone UCHL1)

CD45RO FITC Monoclonal Antibody (Clone UCHL1)is available at Gentaur for Next week Delivery.

Description: CD45, a transmembrane multifunctional glycoprotein, is a member of Type I receptor-linked PTPase family and is expressed as multiple isoforms due to alternative splicing. Expression of these isoforms is highly regulated and shift in this expression determines T-cell activation. CD45RB consists of exon B and is predominantly expressed in naïve T-cells secreting IL-2. Its expression is low in primed/memory T cells, cells that express Th2 cytokines such as IL-4 and IL-10 and population of T-cells with regulatory function. Immunotherapy with CD45RB antibody is being widely studied in transplantation and vaccination. CD45 antibodies are commonly used to identify tumors of lymphoid origin. The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45. CD45RO is a transmembrane glycoprotein with tyrosine phosphatase activity and is expressed by majority of thymocytes, monocytes, granulocytes, and activated memory T lymphocytes. The subsets of peripheral T lymphocytes can be discriminated by using the CD45RO and CD45RA expressing cells.

Immunogen Sequence:Human CD45RO

Target Alternative Name:CD45RO

Species Reactivities:Human

Tag Line:Mouse monoclonal FITC conjugated antibody to detect CD45RO in human samples.

Formulation:Phosphate-buffered aqueous solution pH 7.2, ≤0.09% Sodium azide, may contain carrier protein/stabilizer.

Purification: Affinity chromatography.

Application:Flow cytometry

Positive Control:FACS: Human peripheral blood lymphocytes

Application And Usages:Flow (Cell Surface): 5 µl/1x10^6 cells, Volume per test: 5 µl (0.5 µg).

Handling:The antibody solution should be gently mixed before use.