CD45RA FITC Monoclonal Antibody (Clone HI100)

CD45RA FITC Monoclonal Antibody (Clone HI100)is available at Gentaur for Next week Delivery.

Description: CD45, a transmembrane multifunctional glycoprotein, is a member of Type I receptor-linked PTPase family and is expressed as multiple isoforms due to alternative splicing. Expression of these isoforms is highly regulated and shift in this expression determines T-cell activation. CD45RB consists of exon B and is predominantly expressed in naïve T-cells secreting IL-2. Its expression is low in primed/memory T cells, cells that express Th2 cytokines such as IL-4 and IL-10 and population of T-cells with regulatory function. Immunotherapy with CD45RB antibody is being widely studied in transplantation and vaccination. CD45 antibodies are commonly used to identify tumors of lymphoid origin. The HI100 monoclonal antibody specifically reacts with human CD45RA, the 220 kDa isoform of the human leukocyte common antigen (LCA) found on 40-50% of the peripheral CD4+ T lymphocytes, half of the peripheral CD8+ T lymphocytes and some of the monocytes and B lymphocytes. The CD45RA antigen is expressed by naïve and activated T lymphocytes. The HI100 monoclonal antibody is used as a phenotypic marker to discriminate T lymphocytes subsets.

Immunogen Sequence:Human CD45RA

Target Alternative Name:CD45RA

Species Reactivities:Human

Tag Line:Mouse monoclonal FITC conjugated antibody to detect CD45RA in human samples.

Formulation:Phosphate-buffered aqueous solution pH 7.2, ≤0.09% Sodium azide, may contain carrier protein/stabilizer.

Purification: Affinity chromatography.

Application:Flow cytometry

Positive Control:FACS: Human peripheral blood lymphocytes

Application And Usages:Flow (Cell Surface): 5 µl/1x10^6 cells, Volume per test: 5 µl (1 µg).

Handling:The antibody solution should be gently mixed before use.