BACE Antibody (CT)

BACE Antibody (CT)is available at Gentaur for Next week Delivery.

Description: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-soμght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

Immunogen Sequence:A peptide corresponding to 17 amino acids at the CT of human BACE.

Target Alternative Name:BACE (CT). Asp2

Species Reactivities:Human, mouse

Tag Line:/

Formulation:100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.

Purification: Ion exchange chromatography.

Application:Western blot, Immunohistochemistry, ELISA

Positive Control:Human brain tissue lysate and mouse 3T3 cell lysate

Application And Usages:Immunocytochemistry: 10 μg/ml, Western Blot: 0.5 – 1 μg/ml; ELISA. However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.