Anti-Smad4 Rabbit Monoclonal Antibody

Anti-Smad4 Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF-β and activin-mediated growth modulation. Smad4 has been shown to mediate all of the above activities throμgh interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.

Immunogen Sequence:A peptide corresponding to the C-terminus of human Smad4

Target Alternative Name:SMAD family member, Mothers against decapentaplegic homolog, MAD homolog, Mothers against DPP homolog, SMAD4

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect Smad4 in human samples.

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified

Application:WB, IHC

Positive Control:WB: Jurkat and IMR32 cells lysates, IHC: human breast cancer tissue

Application And Usages:WB: 1:500-1:1000, IHC: 1:1000-1:2000

Handling:The antibody solution should be gently mixed before use.