Anti-CD209 recMAb™ Antibody

Anti-CD209 recMAb™ Antibodyis available at Gentaur for Next week Delivery.

Description: This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region, and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of the infectious disease, including rs4804803, which is associated with SARS severity.

Immunogen Sequence:Recombinant full-length human CD209 protein

Target Alternative Name:CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CIRE, DCSIGN, SIGNR5, SIGN-R1

Species Reactivities:Human

Tag Line:Recombinant rabbit monoclonal antibody to detect the expression of CD209 in human samples

Formulation:In 10 mM PBS

Purification: Protein A/G purified

Application:Immunohistochemistry (IHC)

Positive Control:/

Application And Usages:IHC (1-2 µg/ml)

Handling:The antibody solution should be gently mixed before use.