TPA (311-562), Human Recombinant

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SKU:
P1322-1000
$183
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Description

TPA (311-562), Human Recombinant is available at Gentaur for Next week delivery.

Plays a role in cell migration and tissue remodeling.

Biomolecule/Target: TPA (311-562)

Alternates names: Tissue-type plasminogen activator, EC 3.4.21.68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148, PLAT

Synonyms: Tissue-type plasminogen activator, EC 3.4.21.68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148, PLAT

Background Information: Tissue plasminogen activator (PLAT or tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. TPA Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 261 amino acids (311-562 a.a.) and having a molecular mass of 29.2 kDa (Migrates at 28-40 kDa on SDS-PAGE under reducing conditions). TPA is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Reconstitution Instructions: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time and for long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

NCBI Gene Symbol: PLAT

Gene ID:

NCBI Accession: P00750

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Additional Information

Size:
1 mg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Sf9, Baculovirus cells
Purity by SDS-PAGE:
≥ 95%
Assay:
SDS-PAGE
Molecular Weight:
29.2 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Sterile Filtered colorless solution
Handling:
Centrifuge the vial prior to opening.
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