TPA, Human Recombinant

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SKU:
P1324-20
€185
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Description

TPA, Human Recombinant is available at Gentaur for Next week delivery.

tPA is a serine protease enzyme that converts plasminogen to plasmin.

Biomolecule/Target: TPA

Alternates names: Tissue-type plasminogen activator, EC 3.4.21.68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148.

Synonyms: Tissue-type plasminogen activator, EC 3.4.21.68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148.

Background Information: Tissue plasminogen activator (PLAT or tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Tissue Plasminogen Activator Human Recombinant produced in CHO cells is a single, glycosylated polypeptide chain containing 527 amino acids and having a molecular mass of 59 kDa. tPA is a serine protease enzyme that converts plasminogen to plasmin. The tPA is purified by proprietary chromatographic techniques.

Reconstitution Instructions: It is recommended to reconstitute the lyophilized t-PA in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

NCBI Gene Symbol: PLAT

Gene ID:

NCBI Accession: P00750

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Additional Information

Size:
20 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Chinese Hamster Ovary Cells (CHO)
Purity by SDS-PAGE:
≥ 98.0%
Assay:
SDS-PAGE
Purity:
≥ 98.0%
Assay 2:
RP-HPLC
Molecular Weight:
59 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Sterile Filtered White lyophilized (freeze-dried) powder
Handling:
Centrifuge the vial prior to opening.
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