TNF-alpha Extracellular Domain, Human Recombinant

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SKU:
P1395-50
$183
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Description

TNF-alpha Extracellular Domain, Human Recombinant is available at Gentaur for Next week delivery.

A potent cytokine exerting cytotoxic effects on a wide range of cells

Biomolecule/Target:

Alternates names: TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2

Synonyms: TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2

Background Information: Tumor Necrosis Factor-α (TNF-α) is a highly pleiotropic cytokine with multiple activities other than its originally discovered role of tumor necrosis in rodents. It contributes to both inflammations during infections and anti-inflammatory/tissue repair processes after clearance of infection. TNF-α is mainly produced by activated macrophages, T lymphocytes, and natural killer (NK) cells. The activity of TNF-α is mediated through two cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75) that differ in their signaling activity. TNF-α's primary role is in the regulation of immune cells. It can induce cell death of certain tumor cell lines. About 28% of cancers are susceptible to direct cell killing mediated by soluble TNF-α.

Reconstitution Instructions:

NCBI Gene Symbol: TNFA

Gene ID: 7124

NCBI Accession: P01375

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
False
Source:
CHO cells
Purity by SDS-PAGE:
> 95% by SDS - PAGE
Activity (Specifications/test method):
ED50 is typically < 1 ng/ml. The specific activity was determined by the dose-dependent cytotoxicity of the TNF-alpha sensitive cell line L-929 cells in the presence of the metabolic inhibitor Actinomycin D using BioVision’s Quick Cell Proliferation
Results:
ED50 is typically < 1 ng/ml
Molecular Weight:
18 kDa with a 6×His tag at the C-terminus
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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