Human CellExp™ TNF-alpha Extracellular Domain, Human Recombinant

Human CellExp™ TNF-alpha Extracellular Domain, Human Recombinant is available at Gentaur for Next week delivery.

A potent cytokine exerting cytotoxic effects on a wide range of cells

Biomolecule/Target:

Alternates names: TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2

Synonyms: TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2

Background Information: Tumor Necrosis Factor-α (TNF-α) is a highly pleiotropic cytokine with multiple activities other than its originally discovered role of tumor necrosis in rodents. It contributes to both inflammations during infections and anti-inflammatory/tissue repair processes after clearance of infection. TNF-α is mainly produced by activated macrophages, T lymphocytes, and natural killer (NK) cells. The activity of TNF-α is mediated through two cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75) that differ in their signaling activity. TNF-α's primary role is in the regulation of immune cells. It can induce cell death of certain tumor cell lines. About 28% of cancers are susceptible to direct cell killing mediated by soluble TNF-α.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

NCBI Gene Symbol: TNFA

Gene ID: 7124

NCBI Accession: P01375