Thrombin, Active, Bovine Plasma (High Activity)

Thrombin, Active, Bovine Plasma (High Activity) is available at Gentaur for Next week delivery.

A coagulation protein and a serine protease.

Biomolecule/Target: Thrombin

Alternates names: Activated Factor IIa

Synonyms: Activated Factor IIa

Background Information: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.

Reconstitution Instructions: Reconstitute in sterile water (100 U/ml) with 0.9% NaCl. It forms a clear solution.

NCBI Gene Symbol: F2

Gene ID: 280685

NCBI Accession: P00735