Tau-441, Human Recombinant

Tau-441, Human Recombinant is available at Gentaur for Next week delivery.

Microtubule-associated protein that promotes microtubule assembly and stability.

Biomolecule/Target: MAPT

Alternates names: MAPTL, MTBT1, TAU, Neurofibrillary tangle protein, Paired helical filament-tau

Synonyms: MAPTL, MTBT1, TAU, Neurofibrillary tangle protein, Paired helical filament-tau

Background Information: Tau is a microtubule-associated protein involved in Alzheimer’s and Parkinson’s disease. It promotes microtubule assembly and stability, and might participate in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Reconstitution Instructions: Reconstitute to 4 mg/mL in sterile water.

NCBI Gene Symbol: MAPT

Gene ID: 4137

NCBI Accession: P10636