ST6GalNAc1, soluble fragment, Human Recombinant

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SKU:
P1223-5
£135.37
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Description

ST6GalNAc1, soluble fragment, Human Recombinant is available at Gentaur for Next week delivery.

catalyzes the transfer of sialic acid N-acetylneuraminic acid

Biomolecule/Target: ST6GALNAC1

Alternates names: Beta-1,4-galactosyltransferase 1, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1, Beta-1,4-GalTase 1, Beta4Gal-T1

Synonyms: Beta-1,4-galactosyltransferase 1, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1, Beta-1,4-GalTase 1, Beta4Gal-T1

Background Information: Alpha-N-acetylgalactosaminide α-2,6-sialyltransferase 1 catalyzes the transfer of sialic acid N-acetylneuraminic acid (Neu5Ac) from cytidine 5'-monophosphono-N-acetylneuraminic acid (CMP-Neu5Ac) to O-linked GalNAc residues in an α-2,6 linkage. ST6GalNAcI belongs to a large family of Golgi-membrane-bound sialyltransferases that is responsible for the biosynthesis of sialyated structures, and from which approximately 20 have been cloned to date. The cancer associated sialyl-Tn (sTn) angtigen is formed by ST6GalNAcI, through the transfer of Neu5Ac to GalNAc resiudes on mucins. Addition of a sialic acid to a glyco-protein effectively caps the glycan-chain, preventing further additions. The presence of sialic acid residues extends the half-life of circulating proteins, and are considered to be important for a large variety of biotherapuetics.

Reconstitution Instructions: N/A

NCBI Gene Symbol: ST6GALNAC1

Gene ID: 55808

NCBI Accession: Q9NSC7

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Additional Information

Size:
5 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Insect cells
Purity by SDS-PAGE:
> 90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
Measured by transfer of NeuAc from CMP-NeuAc to the Tn-peptide MEELGMAPALQPT(GalNAc)QGAMPAF.
Biological activity:
Specific activity >50 pmol/min/mg
Results:
> 50 pmol/min/mg
Molecular Weight:
50- 60 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
500 ug/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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