GalNAc-T5, soluble fragment, Human Recombinant

GalNAc-T5, soluble fragment, Human Recombinant is available at Gentaur for Next week delivery.

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis

Biomolecule/Target: GALNT5

Alternates names: Polypeptide N-acetylgalactosaminyltransferase 5, Polypeptide GalNAc transferase 5, GaNTase 5

Synonyms: Polypeptide N-acetylgalactosaminyltransferase 5, Polypeptide GalNAc transferase 5, GaNTase 5

Background Information: Polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) catalyzes the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the hydroxyl group of serine and threonine residues, and was first cloned from rat. Twenty GalNAc-T genes have been identified in humans and most have been shown to represent active GalNAc-Ts. All isoforms are type II transmembrane proteins, with different but partly overlapping substrate preferences. The GalNAc-Ts control the initiation of mucin-type O-linked glycosylation and determine the location and density of O-glycans in a protein. Addition of GalNAc to an unglycosylated Ser/Thr residue creates the Tn antigen GalNAcα1-S/T, and subsequent addition of sialic acid by ST6GalNAc-I forms the cancer associated STn antigen. GalNAc-T5 expression pattern is highly regulated, and is most abundant in salivary glands. GalNAc-T5 has a preference for unglycosylated or monoglycosylated substrates.

Reconstitution Instructions: N/A

NCBI Gene Symbol: GALNT5

Gene ID: 11227

NCBI Accession: Q7Z7M9