SHP-2, Human Recombinant

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SKU:
P1560-50
$719.07
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Description

SHP-2, Human Recombinant is available at Gentaur for Next week delivery.

Activates Erk/MAP kinase pathway by receptor tyrosine kinase signaling.

Biomolecule/Target:

Alternates names: PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2

Synonyms: PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2

Background Information: SHP-2, also known as, tyrosine-protein phospatase non-receptor type 11(PTPN11), is a member of the protein tyrosine phosphatase (PTP) family containing two Src homology 2 domains. This protein dephosphorylation tyrosine residues in proteins. It plays a stimulatory role in the activation of the Erk/MAP kinase pathway by receptor tyrosine kinase signaling. Mutations in this protein are a cause of Noonan syndrome as well as acute myeloid leukemia. Recombinant human SHP-2, fused to His-tag at C-terminus, was expressed in an insect cell and purified by using conventional chromatography techniques.

Reconstitution Instructions:

NCBI Gene Symbol: PTPN11

Gene ID: 5781

NCBI Accession: Q06124

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Additional Information

Size:
50 µg
Adwords:
FAUX
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
VRAI
Source:
HEK 293 cells
Purity by SDS-PAGE:
>90%
Assay:
SDS - PAGE
Endotoxin Level:
< 1 EU per 1ug of protein (determined by LAL method)
Activity (Specifications/test method):
Specific activity is > 400 unit/mg
Molecular Weight:
69.1 kDa ( His-tag at C-terminus)
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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