SHP-2, Human Recombinant

SHP-2, Human Recombinant is available at Gentaur for Next week delivery.

Activates Erk/MAP kinase pathway by receptor tyrosine kinase signaling.

Biomolecule/Target:

Alternates names: PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2

Synonyms: PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2

Background Information: SHP-2, also known as, tyrosine-protein phospatase non-receptor type 11(PTPN11), is a member of the protein tyrosine phosphatase (PTP) family containing two Src homology 2 domains. This protein dephosphorylation tyrosine residues in proteins. It plays a stimulatory role in the activation of the Erk/MAP kinase pathway by receptor tyrosine kinase signaling. Mutations in this protein are a cause of Noonan syndrome as well as acute myeloid leukemia. Recombinant human SHP-2, fused to His-tag at C-terminus, was expressed in an insect cell and purified by using conventional chromatography techniques.

Reconstitution Instructions:

NCBI Gene Symbol: PTPN11

Gene ID: 5781

NCBI Accession: Q06124