Caspase-2, human recombinant

Caspase-2, human recombinant is available at Gentaur for Next week delivery.

A cysteine protease involved in apoptosis

Biomolecule/Target: Caspase-2

Alternates names: Caspase-2, CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1

Synonyms: Caspase-2

Background Information: Caspase-2 (also know as Ich-1, Nedd-2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-2 also exists in cells as an inactive proenzyme. During apoptosis pro-caspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed active caspase-2 is a heterotetramer consisting of two large (19 kDa) and two small (12 kDa) subunits.The recombinant active human caspase-2 was expressed in E. coli. The active caspase-2 preferentially cleaves caspase-2 substrates (e.g., VDVAD-AFC or VDVAD-pNA) and is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-VDVAD-pNA (Cat. #1072-200) or Ac-VDVAD-AFC (1071-200).

Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS containing 15% glycerol.

NCBI Gene Symbol: CASP2

Gene ID: 835

NCBI Accession: P42575