Recombinant SARS-CoV-2 Papain-like Protease

Recombinant SARS-CoV-2 Papain-like Protease is available at Gentaur for Next week delivery.

Replicase polyprotein essential for generating a functional replication complex

Biomolecule/Target:

Alternates names: PLPro, PL-PRO, pp1a, Papain-like Protease, Replicase polyprotein 1a, ORF1a polyprotein, Plpro

Synonyms: PLPro, PL-PRO, pp1a, Papain-like Protease, Replicase polyprotein 1a, ORF1a polyprotein, Plpro

Background Information: SARS-CoV is an enveloped, single and positive-stranded RNA virus. Replication of the genomic RNA of SARS-CoV is mediated by replicase polyproteins that are processed by two viral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro). The chymotrypsin-like 3CLpro processes the replicase polyprotein at 11 sites, including cleaving itself from the polyprotein to generate a ∼25-kDa protease product. Papain-like proteases have been shown to process the amino-terminal end of the replicase polyprotein to generate two or three replicase products. Proteolytic processing of the coronavirus replicase polyprotein is essential for generating a functional replication complex. Therefore, the coronavirus replicase-encoded proteases, 3CLpro and PLpro, are potential targets for antiviral drug development.

Reconstitution Instructions:

NCBI Gene Symbol:

Gene ID:

NCBI Accession: YP_009725299.1