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Recombinant Human Soluble Interleukin-6 (IL-6) Receptor

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Description

Recombinant Human Soluble Interleukin-6 (IL-6) Receptor is available at Gentaur for Next week delivery.

>98% Pure, Active, Human Recombinant Soluble Interleukin-6 (IL-6) Receptor

Biomolecule/Target: Interleukin-6 (IL-6) Receptor

Alternates names: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Synonyms: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Background Information: The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component specific to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low affinity binding sites for IL-6 is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6 kDa protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.

NCBI Gene Symbol: IL6R

Gene ID: 3570

NCBI Accession: P08887

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Additional Information

Size:	20 µg
Country of Manufacturing Origin:	USA
Country of Animal Origin:	USA
Gene Source:	Human
Recombinant:	Yes
Source:	CHO cells
Purity by SDS-PAGE:	≥98%
Assay:	SDS-PAGE
Purity:	N/A
Assay 2:	N/A
Endotoxin Level:	N/A
Activity (Specifications/test method):	The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Biological activity:	The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Results:	The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Molecular Weight:	37.6 kDa
Storage Temperature:	-20°C
Shelf Life:	12 months
Concentration:	N/A
Appearance:	Lyophilized
Handling:	Centrifuge the vial prior to opening.