BioVision Products
Recombinant Human Soluble Interleukin-6 (IL-6) Receptor
- SKU:
- 4598-20
Description
Recombinant Human Soluble Interleukin-6 (IL-6) Receptor is available at Gentaur for Next week delivery.
>98% Pure, Active, Human Recombinant Soluble Interleukin-6 (IL-6) Receptor
Biomolecule/Target: Interleukin-6 (IL-6) Receptor
Alternates names: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126
Synonyms: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126
Background Information: The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component specific to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low affinity binding sites for IL-6 is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6 kDa protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
NCBI Gene Symbol: IL6R
Gene ID: 3570
NCBI Accession: P08887
Additional Information
Size: |
20 µg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
CHO cells |
Purity by SDS-PAGE: |
≥98% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6. |
Biological activity: |
The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6. |
Results: |
The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6. |
Molecular Weight: |
37.6 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |