PTEN, human recombinant

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SKU:
4838-5
$183
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Description

PTEN, human recombinant is available at Gentaur for Next week delivery.

A tumour supressor protein

Biomolecule/Target:

Alternates names: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del,

Synonyms: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, Mutated in Multiple advanced cancers 1, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del,

Background Information: PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.

Reconstitution Instructions: N/A

NCBI Gene Symbol: PTEN

Gene ID: 5728

NCBI Accession: P60484

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Additional Information

Size:
5 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
<0.1 ng/μg
Activity (Specifications/test method):
Not available at this time
Biological activity:
A Phosphatase specific activity of ≥ 400 nmol/min/mg was determined using the substrate phosphatidylinositol (3,4,5) triphosphate at a final concentration of 125 mM in 20 mM Tris, pH 7.5, 150 mM NaCl, 50 mM MgCl2, 0.05 % Tween-20, 0.2 % 2-mercaptoeth
Results:
N/A
Molecular Weight:
80.0 kDa (GST tagged)
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
100 µg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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