Description
PTEN, human recombinant is available at Gentaur for Next week delivery.
A tumour supressor protein
Biomolecule/Target:
Alternates names: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del,
Synonyms: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, Mutated in Multiple advanced cancers 1, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del,
Background Information: PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.
Reconstitution Instructions: N/A
NCBI Gene Symbol: PTEN
Gene ID: 5728
NCBI Accession: P60484
Additional Information
Size: |
5 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli |
Purity by SDS-PAGE: |
≥90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
<0.1 ng/μg |
Activity (Specifications/test method): |
Not available at this time |
Biological activity: |
A Phosphatase specific activity of ≥ 400 nmol/min/mg was determined using the substrate phosphatidylinositol (3,4,5) triphosphate at a final concentration of 125 mM in 20 mM Tris, pH 7.5, 150 mM NaCl, 50 mM MgCl2, 0.05 % Tween-20, 0.2 % 2-mercaptoeth |
Results: |
N/A |
Molecular Weight: |
80.0 kDa (GST tagged) |
Storage Temperature: |
-80°C |
Shelf Life: |
12 months |
Concentration: |
100 µg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |