Nicotinamide N-Methyltransferase, Human Recombinant (hNNMT)

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SKU:
7261-20
£135.37
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Description

Nicotinamide N-Methyltransferase, Human Recombinant (hNNMT) is available at Gentaur for Next week delivery.

A cytosolic methyltransferase catalyzing the N-methylation of nicotinamide

Biomolecule/Target: NNMT

Alternates names: NNMT

Synonyms: NNMT

Background Information: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

Reconstitution Instructions: N/A

NCBI Gene Symbol: NNMT

Gene ID: 4837

NCBI Accession: P40261

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Additional Information

Size:
20 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥98%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
31.7 kDa (263aa + NT 6xHis-tag)
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
3.42 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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