BioVision Proteins
Glycine N-methyltransferase, Human Recombinant
- SKU:
- P1235-50
Description
Glycine N-methyltransferase, Human Recombinant is available at Gentaur for Next week delivery.
Regulate tissue concentration of AdoMet and metabolism of methionine.
Biomolecule/Target: GNMT
Alternates names: GNMT
Synonyms: GNMT
Background Information: Glycine N-methyltransferase, also known as GNMT, catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. This protein affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and participates in the detoxification pathway in liver cells. Also it is reported that GNMT expression is diminished in human hepatocellular carcinoma (HCC). Recombinant human GNMT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Reconstitution Instructions: N/A
NCBI Gene Symbol: GNMT
Gene ID: 27232
NCBI Accession: Q14749
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E.coli |
Purity by SDS-PAGE: |
> 95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
< 1.0 EU per/μg |
Activity (Specifications/test method): |
Measured by its ability to transfer 1.0 nmole of methyl group per minute at 37C. |
Biological activity: |
Specific activity > 100 nmol/min/mg |
Results: |
>100 nmol/min/mg |
Molecular Weight: |
34.9 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |