Description
Mouse Recombinant DHFR is available at Gentaur for Next week delivery.
Reduces dihydrofolic acid to tetrahydrofolic acid
Biomolecule/Target:
Alternates names: Dihydrofolate reductase.
Synonyms: Mouse Recombinant DHFR
Background Information: Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and it is essential for the synthesis of thymidylate, purines and several amino acids. Expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.
Reconstitution Instructions: N/A
NCBI Gene Symbol: DHFR
Gene ID: 13361
NCBI Accession: P00375
Additional Information
Size: |
100 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Mouse |
Recombinant: |
Yes |
Source: |
E. Coli |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Specific activity is > 0.2 units/mg and was obtained by measuring the oxidation of NADPH in absorbance at 340 nm during reaction. |
Results: |
>0.2 units/mg |
Molecular Weight: |
23.8 kDa (207 aa, 1-187 aa + NT His-Tag) |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
1 mg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |
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