LRIG1, Mouse Recombinant

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SKU:
P1557-50
$719.07
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Description

LRIG1, Mouse Recombinant is available at Gentaur for Next week delivery.

Tumor suppressor, negative regulator of the EGF

Biomolecule/Target:

Alternates names: LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1

Synonyms: LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1

Background Information: LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse. Recombinant mouse LRIG1, fused to His-tag at Cterminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Reconstitution Instructions:

NCBI Gene Symbol: Lrig1

Gene ID: 16206

NCBI Accession: P70193

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Additional Information

Size:
50 µg
Adwords:
FAUX
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
VRAI
Source:
Baculovirus
Purity by SDS-PAGE:
>90%
Assay:
SDS - PAGE
Endotoxin Level:
< 1 EU per 1 ug of protein (determined by LAL method)
Molecular Weight:
84.8 kDa (His-tag at C terminus)
Storage Temperature:
-20ºC
Shelf Life:
12 months
Concentration:
0.5 mg/ml (determined by Bradford assay)
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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