K63-linked Tri-Ubiquitin

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SKU:
6419-50
£135.37
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Description

K63-linked Tri-Ubiquitin is available at Gentaur for Next week delivery.

Substrate for defined length polyubiquitination

Biomolecule/Target:

Alternates names:

Synonyms: K63-linked Tri-Ubiquitin

Background Information: Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked polyubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, and neurodegeneration. These tri-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for a lysine at position 63, limiting chain length.

Reconstitution Instructions: N/A

NCBI Gene Symbol: N/A

Gene ID: N/A

NCBI Accession: N/A

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Rabbit
Recombinant:
N/A
Source:
N/A
Purity by SDS-PAGE:
≥95%
Assay:
Western Blot
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
25.686 kDa (Band migrates faster on gels)
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
2.5 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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