Irisin, Active, human recombinant

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SKU:
7852-50
£135.37
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Description

Irisin, Active, human recombinant is available at Gentaur for Next week delivery.

Activates beige fat cells

Biomolecule/Target: Irisin

Alternates names: Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved).

Synonyms: Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved).

Background Information: Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.

Reconstitution Instructions: Reconstitute to 0.1 mg/ml with sterile water

NCBI Gene Symbol: FNDC5

Gene ID: 252995

NCBI Accession: Q8NAU1

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Additional Information

Size:
50 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
Irisin treatment stimulates UCP-1 expression in 3T3-L1 derived adipocyte
Biological activity:
N/A
Results:
N/A
Molecular Weight:
~13.00 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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