INS, 25-110 aa, His-tag, Human Recombinant

INS, 25-110 aa, His-tag, Human Recombinant is available at Gentaur for Next week delivery.

Essential hormone for maintaining metabolic homeostasis

Biomolecule/Target: INS

Alternates names: Insulin preproprotein , IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10

Synonyms: Insulin preproprotein , IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10

Background Information: INS, also known as insulin preproprotein, is a biologically inactive precursor to the biologically active endocrine hormone insulin. Insulin is an essential hormone for maintaining metabolic homeostasis in the body. To make fully bioactive insulin, pancreatic beta cells initiate synthesis of INS. It is converted into proinsulin by signal peptidases, which remove its signal peptide from its N-terminus. Finally, proinsulin is converted into the bioactive hormone insulin by removal of the C-peptide. Recombinant human INS, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques.

Reconstitution Instructions:

NCBI Gene Symbol: INS

Gene ID: 3630

NCBI Accession: NP_000198