IL-12, human recombinant

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SKU:
4161-100
$183
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Description

IL-12, human recombinant is available at Gentaur for Next week delivery.

A T cell-stimulating factor

Biomolecule/Target: IL-12

Alternates names: NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-α, IL-12

Synonyms: NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-α, IL-12

Background Information: IL-12 is a potent regulator of cell mediated immune responses and in induces IFN-g production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN-g producing Th1 cells. Recombinant human IL-12 is a 75 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

Reconstitution Instructions: Reconstitute in 1X PBS (pH 7.2-7.4) to a concentration of 0.2 mg/ml. The solution can then diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

NCBI Gene Symbol: IL12

Gene ID: 3592

NCBI Accession: P29459

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Additional Information

Size:
100 μg
Adwords:
Yes-SG
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
CHO cells
Purity by SDS-PAGE:
≥98%
Assay:
SDS-PAGE
Purity:
≥98%
Assay 2:
HPLC
Endotoxin Level:
<0.1 ng/μg
Activity (Specifications/test method):
N/A
Biological activity:
The ED₅₀ as determined by the induction of IFN-g production from murine splenocytes co-stimulated with IL-12 is <0.1 ng/ml, corresponding to a specific activity of > 1 x 10⁷ units/mg.
Results:
<0.1 ng/ml,
Molecular Weight:
75.0 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized protein
Handling:
Centrifuge the vial prior to opening.
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