Description
IL-12, human recombinant is available at Gentaur for Next week delivery.
A T cell-stimulating factor
Biomolecule/Target: IL-12
Alternates names: NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-α, IL-12
Synonyms: NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-α, IL-12
Background Information: IL-12 is a potent regulator of cell mediated immune responses and in induces IFN-g production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN-g producing Th1 cells. Recombinant human IL-12 is a 75 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).
Reconstitution Instructions: Reconstitute in 1X PBS (pH 7.2-7.4) to a concentration of 0.2 mg/ml. The solution can then diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
NCBI Gene Symbol: IL12
Gene ID: 3592
NCBI Accession: P29459
Additional Information
Size: |
100 μg |
Adwords: |
Yes-SG |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
CHO cells |
Purity by SDS-PAGE: |
≥98% |
Assay: |
SDS-PAGE |
Purity: |
≥98% |
Assay 2: |
HPLC |
Endotoxin Level: |
<0.1 ng/μg |
Activity (Specifications/test method): |
N/A |
Biological activity: |
The ED₅₀ as determined by the induction of IFN-g production from murine splenocytes co-stimulated with IL-12 is <0.1 ng/ml, corresponding to a specific activity of > 1 x 10⁷ units/mg. |
Results: |
<0.1 ng/ml, |
Molecular Weight: |
75.0 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized protein |
Handling: |
Centrifuge the vial prior to opening. |