Hydroxyacid Oxidase-1/HAO-1, Human Recombinant

Hydroxyacid Oxidase-1/HAO-1, Human Recombinant is available at Gentaur for Next week delivery.

Member of the α-­hydroxy superfamily, oxidizes glycolic acid to glyoxylate.

Biomolecule/Target:

Alternates names: HAOX1, Glycolate Oxidase, GOX, HAO1, GOX1

Synonyms: HAOX1, Glycolate Oxidase, GOX, HAO1, GOX1

Background Information: Glycolate oxidase is a member of the superfamily of the α­hydroxy acid oxidases (HAO), enzymes that are present in both plants and animals. It catalyzes the FMN­mediated oxidation of glycolate to glyoxylate and glyoxylate to oxalate with reduction of oxygen to hydrogen peroxide. The co­factor, FMN, is tightly bound but not covalently linked to the protein. In humans and other vertebrates, HAOs are found primarily in the peroxisomes of liver, kidney, and pancreas. Three HAOs have been identified in humans. HAO­1 is most highly expressed in liver and pancreas and is most active on glycolate, two­carbon substrates. Glycolate oxidase oxidizes glycolic acid to glyoxylate, and can also oxidize glyoxylate into oxalate. These reactions are central to the toxicity of ethylene glycol poisoning. Recently, HAO has been identified as a major contributor to hyperoxaluria, a disorder in which large deposits of calcium oxalate form kidney stones.

Reconstitution Instructions:

NCBI Gene Symbol: HAO1

Gene ID: 54363

NCBI Accession: Q9UJM8