Human CellExp™ TNFSF11 / RANKL / CD254, Human Recombinant

Human CellExp™ TNFSF11 / RANKL / CD254, Human Recombinant is available at Gentaur for Next week delivery.

Tumor necrosis factor ligand superfamily member 11 stimulates osteoclast formation.

Biomolecule/Target: TNFSF11

Alternates names: RANKL, CD254, TRANCE, OPGL, ODF

Synonyms: RANKL, CD254, TRANCE, OPGL, ODF

Background Information: Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: TNFSF11

Gene ID: 8600

NCBI Accession: O14788