Human CellExp™ TNFRSF10, Fc Tag, Human Recombinant

Human CellExp™ TNFRSF10, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.

Apoptosis inducer

Biomolecule/Target:

Alternates names: Apo-2L, TRAIL, CD253, TNFSF10, Apo-2 ligand

Synonyms: Apo-2L, TRAIL, CD253, TNFSF10, Apo-2 ligand

Background Information: TRAIL, also known as TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A and TNF superfamily member 10. The TRAIL gene as a drug target, induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: TNFSF10

Gene ID: 8743

NCBI Accession: P50591