Human CellExp™ TNFR1 / CD120a / TNFRSF1A, human recombinant

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SKU:
7382-50
$719.07
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Description

Human CellExp™ TNFR1 / CD120a / TNFRSF1A, human recombinant is available at Gentaur for Next week delivery.

Contributes to the induction of non - cytocidal TNF effects

Biomolecule/Target: TNFR1 / CD120a / TNFRSF1A

Alternates names: TNFR1, CD120a, TNFRSF1A, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR55, TNFR60, p55, p60.

Synonyms: TNFR1, CD120a, TNFRSF1A, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR55, TNFR60, p55, p60.

Background Information: Tumor necrosis factor receptor 1 (TNF-R1) also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial Hibernian fever (FHF).

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: TNFRSF1A

Gene ID: 7132

NCBI Accession: P19438

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
≥92%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<1 EU/μg by LAL method
Activity (Specifications/test method):
N/A
Biological activity:
Measured by its binding ability in a functional ELISA. Immobilized human TNFα at 10 μg/mL (100 μl/well) can bind biotinylated human TNFRSF1A. The EC50 of biotinylated human TNFRSF1A is 0.02 μg/mL.
Results:
Measured by its binding ability in a functional ELISA. Immobilized human TNFα at 10 μg/mL (100 μl/well) can bind biotinylated human TNFRSF1A. The EC50 of biotinylated human TNFRSF1A is 0.02 μg/mL.
Molecular Weight:
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 22 kDa. The predicted N-terminus is Ile 22. DTT-reduced Protein migrates as 30-35 kDa due to different glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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