Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant

Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant is available at Gentaur for Next week delivery.

Mediate phagocytosis of apoptotic cells and inhibit aggressive Th1-mediated auto- and alloimmune responses.

Biomolecule/Target:

Alternates names: HAVCR2, TIM3, TIMD3, FLJ14428, KIM3

Synonyms: HAVCR2, TIM3, TIMD3, FLJ14428, KIM3

Background Information: Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water. Do not vortex. It is recommended to store at -20°C.

NCBI Gene Symbol:

Gene ID:

NCBI Accession: EHH54703