Human CellExp™ TIGIT, human recombinant

Human CellExp™ TIGIT, human recombinant is available at Gentaur for Next week delivery.

>95% Pure, Human cell expressed TIGIT

Biomolecule/Target: TIGIT

Alternates names: TIGIT, VSIG9, VSTM3

Synonyms: TIGIT, VSIG9, VSTM3

Background Information: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.

NCBI Gene Symbol: TIGIT

Gene ID: 201633

NCBI Accession: Q495A1